My take on this theme is the dreaded Stomach Bug. 

Play as a retrovirus and assimilate an army of nasty cells in the belly of your host. As you play you will be surrounded by an increasingly large army, mutated by your RNA, and the hosts white blood cells which will feast upon them. It's an arcade shoot-em-up where the goal is only a high score. 

Controls: arrow keys to move, left click to fire OR right click to move, left click to fire.

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Its a pretty fun game and its hard to get a good score!  Its a simple idea and its executed pretty well.. Maybe if you made a goal for the player and then switch things up when they reach the goal but, that is just what i would do and is your game.. Overall its a pretty fun game!

For what it's worth: my high score is only 21 because I'm bad at vidya games.